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Movantik contains the active ingredient naloxegol. Moreover, this medication belongs to a drug class called peripherally-acting mu-opioid receptor antagonists (PAMORAs). PAMORAs lessen constipation without reducing the pain relief offered by opioids. Of note, they work differently than standard laxatives as OIC is different than normal constipation. Specifically, Movantik works to treat constipation by preventing opioids from binding to the mu receptors (a class of opioid receptors) in the digestive tract....

Paulo Dybala? Not quite. The player in question Sporting’s 25-year-old wideman Marcos Acuna, who is now looking to consolidate his success with Argentina by causing a massive Champions League upset at the expense of Dybala and Juventus. Few would have guessed at the start of 2017 that it would be Acuna, not Dybala, soaking up the plaudits in Argentina. The native of Zapala, a wind-swept city of some 35,000 inhabitants in the heart of Patagonia, had a similar football upbringing to his fellow small-town hero, coming up through the ranks at Ferro in the Nacional B and locking horns with Instituto’s teenage wonderkid in that notoriously punishing division....

Installed as Espanyol’s new manager and tasked with dragging it from the relegation mire, the former defender had quite the first test: Barcelona away and Pep Guardiola in the opposite dugout. Guardiola’s men were in dazzling form, an irrepressible winning machine. And yet Pochettino’s underdogs turned up, in their great rivals’ back yard, and won 2-1. A high press stunned the home side, so used were they to having to break teams down....

That’s not entirely a good thing. If you’re not paying attention, your iTunes library can quickly take up more than its fair share of drive space. Moving your iTunes library from its original location to another internal or external drive can free up some room. It can also give you more space to grow your collection. How to Move Your iTunes Library to a New Location This process retains all your iTunes settings, including playlists, ratings, and all media files....

Sunderland go into the Anfield clash on the back of consecutive wins in the Premier League and have lifted themselves off the bottom of the table in the process. Defoe the shining light for Sunderland But Moyes is not optimistic about extending that run when he returns to Merseyside, with Liverpool just a point behind pacesetters Chelsea and Jurgen Klopp’s side the highest-scoring club in the division with 30 goals....

So far, nearly a million people have lost their homes in this impoverished African nation. Though the official death count is less than 300, aid workers fear it will climb well into the thousands as floodwaters recede. And with food scarce and livestock rotting in the water, the tragedy can only get worse as hunger and disease begin to spread. According to the Christian aid group World Vision, a tiny local hospital near the capital of Maputo has been treating nearly 350 people a day, 90 percent of whom are suffering from malaria....

That’s no longer true, thanks to the ever-spreading MP3 revolution. Once the province of desktop PCs and portable music players, MP3 technology is making its way into car-stereo products like the Kenwood Music Keg. The device consists of three parts: a 10-gigabyte removable hard drive, a USB docking cradle that connects to your PC and the in-car or trunk-mounted Music Keg. To copy music from your PC, you simply place the hard disk in the cradle and transfer your songs and playlists, then take the hard drive over to your vehicle and pop it into the Music Keg....

What Is an MP4V File? MP4V stands for MPEG-4 video. It was created by Moving Pictures Experts Group (MPEG) as a codec used to compress and decompress video data. You probably won’t see a video file that has the .MP4V file extension. However, if you do, it can still open in a multi-format media player. We have some MP4V players listed below. If you see “MP4V” in the context of a video file, it just means the video was compressed with the MP4V codec....

Worldover Cricket is recognised as an enigmatic sport. It is followed as a game that transcends geographies, bridges the gap between its lovers and stars and ultimately, unites fans regardless of age or colour. The way cricket is adored by millions across the globe is not only fascinating for numerous reasons but brings to light its power to evoke responses that mold the way the game is percieved and regarded....

A lot of times I would give her the lines and tell her what I wanted her to say. Then I’d ask her how she would say that. She was 21 and I was 112. I don’t know the young way of saying things. She didn’t know why I liked what she said. She was very brave to try it like that. She had that Audrey Hepburn thing, but she was also Lucy....

This MSI monitor costs $449.99 at online retailers such as Newegg, and it promises specs like 1ms response time and 165Hz refresh rate on a 27-inch, 2560x1440 wide quad high definition (WQHD) display. The ample screen space for what the monitor purports to hit is no doubt its best selling point, as this offers up both a large area to project one’s games and to use for work purposes. Multiple windows can very comfortably sit on the display, allowing for a number of different activities to go on at once - including having a game open with something like a Discord chat running beside it....

To get the job done, the Prestige 15’s exterior boasts diamond-cut edges and sandblasted textures. On the inside you’ll find one of Intel’s latest processors alongside dedicated Nvidia graphics. When more of us than ever before are blurring the lines between home and work – and when more people use the same laptop for both – it’s important to have a one that can tackle every task. Given that situation it’s unsurprising that the MSI faces some strong contenders....

Third seed Muguruza was triumphant at Roland Garros 12 months ago and the Spaniard, last year’s semi-finalist in Rome, proved too good for Julia Goerges in a 7-5 6-4 victory. Halep, a victor on clay at the Madrid Open on Saturday, was dominant for the most part against Anastasia Pavlyuchenkova but had to regain her composure in a 6-1 4-6 6-0 success. MARVELLOUS MUGURUZA ON THE MARCH Just 24 hours on from a gruelling three-set win over Jelena Ostapenko, Muguruza was back in action in the Italian capital....

Afghanistan ran out 3-0 winners in the Twenty20 international series and were again comfortable in the 50-over format, winning by five wickets. Mujeeb took superb figures of 3-14, while Dawlat Zadran passed 100 ODI wickets with 3-35, as Ireland were limited to 161 all out. That meagre total allowed Afghanistan to coast and there were 49 balls remaining when Najibullah Zadran - 12 not out off three balls - smashed the match-clinching six, taking his side to 165-5....

The driver, a woman, is in police custody after having struck six people. One of the people is in serious condition with the other five having minor injuries, according to SpotNews.tv. Two law enforcement sources said that protesters surrounded the driver’s car, tapping and pounding on it, which caused the panicked driver to speed away while plowing through protestors, according to WNBC-TV. However, a witness told the media outlet that the protest had been peaceful before the driver struck the pedestrians....

Under normal conditions, it almost never does. Women’s hormonal rhythms are choreographed to ensure that the ovaries release one–and only one–fertile egg every month. Early in the menstrual cycle, a drop in circulating estrogen and progesterone prompts the body to release other hormones (GRF, FSH and LH). When stimulated by those hormones, egg-bearing sacs, or follicles, within the ovaries start to swell. After a week or so, a follicle will mature to the point where it’s ready to release its egg into the fallopian tube for fertilization....

The Wales international has been linked with a move to United amid talk of Madrid’s pursuit of Monaco star Kylian Mbappe. Mourinho said he would consider Bale to be available if he were left on the bench for the UEFA Super Cup against United on Tuesday, but the 28-year-old started alongside Karim Benzema and set up Isco to score his side’s second in their 2-1 victory. And the United manager accepts that any chance of bringing the former Tottenham man back to the Premier League appear to be over....

The Red Devils are eighth in the Premier League after 12 matches, having conceded a whopping 21 goals and already seem to be out of the title race after suffering four defeats. Their most recent loss came just before the international break at the hands of Manchester City, which left them 12 points adrift of their arch-rivals at the top of the table. However, Mourinho remains defiant in the face of adversity and has insisted in a press conference on Friday that his players can turn things around before the new year....

United thumped lowly Crystal Palace in comprehensive fashion at Old Trafford, with Juan Mata, Romelu Lukaku and Marouane Fellaini’s brace doing the damage. 11/2 for Brighton and Arsenal to draw It represents their fourth 4-0 triumph of the campaign, but Mourinho was left disappointed by elements of his side’s display. “Three points were very important,” Mourinho told Sky Sports. “I told the players we had to respect and play seriously against an opponent in a difficult situation but are better than the results are saying....